esmo 2017 hypersensitivity

Monitor. The https:// ensures that you are connecting to the J. Gynecol. Efficacy and Adverse Events of Carboplatin Desensitisation Therapy for Gynaecological Cancer: A Retrospective Study. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Death from anaphylaxis to cisplatin: a case report. Carboplatin and other paltins, Algorithm for the evaluation of drug hypersensitivity reactions and the role of desensitization. Check the latest publications and updates here to make sure you dont miss anything. This analysis includes 4772 pts. Necessary cookies enable core functionality. ESMO Colloquia are innovative sessions within the Congress programme, organised by ESMO and supported by industry, Information about the exhibition and Satellite Symposia, Contact details and welcome message, plus other general information about ESMO 2017. FOIA The median patient age was 56 years (range 1694 years). Unauthorized use of these marks is strictly prohibited. The annual ESMO Congress is the most prestigious and influential oncology platform in Europe and is the ideal place to learn about the latest science, network with colleagues and keep pace with today's rapid developments in cancer research. Table 4. del Carmen Sancho M, Breslow R, Sloane D, Castells M. Chem Immunol Allergy. Carboplatin hypersensitivity. CA. However, prolonged carboplatin use is associated with an increased incidence of carboplatin-related hypersensitivity reactions (Markman et al., 1999; Wang et al., 2009). Before doi: 10.3802/jgo.2013.24.4.342, Confino-Cohen, R., Fishman, A., Altaras, M., and Goldberg, A. Table 7. Author Mariana Castells 1 Affiliation 1 Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Cancer. Patients with prior drug or food allergies should be closely monitored during carboplatin administration. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. Koshiba et al. Type II hypersensitivity is an IgG or IgM antibody-dependent cytotoxicity in which an antigen attached to cell membranes of red blood cells or platelets binds to an antibody, leading to cell or tissue damage such as haemolytic anaemia or thrombocytopenia. Supportive. Br. Support for third-party writing assistance for this abstract, furnished by Alison McGonagle, PhD, of Health Interactions, was provided by F. Hoffmann-La Roche Ltd., Basel, Switzerland. Patients should be observed closely for hypersensitivity reactions for a minimum of 30 minutes following each IV iron . 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ESMO 2017 was held in partnership with the European Association for Cancer Research (EACR) in Madrid . A total of 735 eligible women who underwent treatment for ovarian, fallopian tube, or primary peritoneal cancer were recruited this the study; 75 (10.2%) experienced a total of 215 carboplatin-related hypersensitivity reaction events. Gynecol. 2018 Oct 1;29(Suppl 4):iv260. 2023 Feb 15;24(4):3886. doi: 10.3390/ijms24043886. The cumulative incidence of carboplatin-related hypersensitivity was 2% at >3,500 mg, 6% at >7,500 mg, 8% at >10,000 mg, and 10% at >16,000 mg with a plateau beyond this dose (Figure 1B). This site uses cookies. Analysis included treatment cycle, causative drug, severity of reaction as per CTCAE v4 . Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. HHS Vulnerability Disclosure, Help In an era of deep understanding of the molecular biology underlying the development of cancer, it is crucial that researchers and clinicians exchange knowledge. Incidence of carboplatin-related hypersensitivity reactions in Japanese patients with gynecologic malignancies. Int. (1994). government site. Rosell S, Blasco I, Garca Fabregat L, Cervantes A, Jordan K; ESMO Guidelines Committee. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23, Published in 2020 Ann Oncol (2020)Authors:M.E. The dilemma of carboplatin-associated hypersensitivity reactions in ovarian cancer management. We found a higher incidence of carboplatin-related hypersensitivity among patients with advanced disease (stage IIIIV) with serous carcinoma and malignant ascites. The independent sample t-test was used to evaluate how carboplatin cycle and dose correlated with the incidence of hypersensitivity and severe hypersensitivity reactions. This Webinar series brings together all the relevant stakeholders who are developing each guideline, as well as those who are consulting and implementing the guideline. Necessary cookies enable core functionality. (2015). Upon the occurrence of symptoms and signs, carboplatin infusion was immediately stopped. Most IRs are mild with symptoms such as chills, fever, nausea, headache, skin rash, pruritus, etc. Necessary cookies enable core functionality. These new ESMO Clinical Practice Guidelines provide tools to evaluate the risk of infusion reactions, to recognise the early signs and symptoms and include recommendations on how to document and manage them. MeSH ESMO is a Swiss-registered not-for-profit organisation. Gynecol. The overall safety profile was similar between subgroups. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. In 74 of the 75 patients, the hypersensitivity reactions subsided within several minutes to several hours after onset, and the patients recovered without any sequelae. We also collected survey data from cancer nurses on safety . Though the characteristics of carboplatin-related hypersensitivity reactions are widely reported, limited data are available regarding such reactions in different types of patients. Front Oncol. E. Restuccia: Financial Interests, Personal, Full or part-time Employment: F. Hoffmann-La Roche Ltd.; Financial Interests, Personal, Stocks/Shares: Genentech, Inc; Non-Financial Interests, Personal, Research Grant, Medical writing support: F. Hoffmann-La Roche Ltd. S. 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Hoffmann-La Roche Ltd.; Financial Interests, Institutional, Advisory Board: MSD. Wang, H. B., Shen, K., Yang, J. X., Huang, H. F., Li, Y., Wu, M., et al. Compared to those without hypersensitivity reactions, women who experienced hypersensitivity reactions had a significantly higher median number of cycles (12 vs. 6, P < 0.001, independent sample t-test) and dose (6,816 vs. 3,844 mg, P < 0.001, independent sample t-test, Table 3). Ann Oncol. Chemother. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. We assessed occurrence, incidence and severity of these events in key Roche clinical trials of PH IV/PH FDC SC, and did a timetrend analysis (by cycle) for metastatic BC (MBC) and early BC (EBC) studies. Met Based Drugs (2010) 2010 Available from: Markman M. Toxicities of the platinum antineoplastic agents. ESMO Call to Action on COVID-19 Vaccinations and Patients with Cancer: Vaccinate. Carboplatin induces DNA double strand breaks, which are repaired by BRCA recombination repair enzymes. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Integrating science into oncology for a better patient outcome, ESMO Designated Centres Community Session, Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the. (2009). doi: 10.1200/JCO.2009.25.7519, Schwartz, J. R., Bandera, C., Bradley, A., Brard, L., Legare, R., Granai, C. O., et al. Thus, we chose the cumulative carboplatin dose for the analysis to avoid interference between the highly correlated factors. Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions. Therefore, the preferred regimen for platinum-sensitive recurrent ovarian cancer is carboplatin combined with paclitaxel, liposomal doxorubicin, or gemcitabine. Monitor. In Taiwan, carboplatin was first introduced for the treatment of ovarian cancer in 2004. A sincere thanks to the almost 24,000 participants who attended this year's annual congress! Whether desensitization modulates drug allergic and anaphylactic responses facilitating tolerance is currently being investigated. It would be worthwhile to evaluate the correlation between other HRD genes and carboplatin hypersensitivity. Compared to women without hypersensitivity reactions, women who experienced hypersensitivity reactions had a significantly greater median cycle number (12 vs. 6, P < 0.001, independent sample t-test) and dose (6,816 vs. 3,844 mg, P < 0.001, independent sample t-test). Galateanu B, Pucau AI, Tircol SA, Tanase BC, Hudita A, Negrei C, Burcea-Dragomiroiu GT, Negreanu L, Vacaroiu IA, Ginghin O. Int J Mol Sci. doi: 10.1038/bjc.2013.389, Navo, M., Kunthur, A., Badell, M. L., Coffer, L. W. Lacouture, V. Sibaud, P.A. J. Ann. Cancer. Classical and new chemotherapy drugs, monoclonal antibodies (MoAbs), and small molecules to treat cancer and chronic inflammatory diseases are aimed at improving quality of life and life expectancy of patients, but an increasing number of reactions including anaphylaxis precludes their use in targeted populations. Drug Interactions in the Treatment of Malignancy in HIV-Infected Patients. Pediatric. (2010). Chan. All funding for this site is provided directly by ESMO. Close monitoring is warranted for patients with a history of drug or food allergy, malignant ascites, or cumulative carboplatin dose >4,000 mg. Strategies for preventing carboplatin-related hypersensitivity include reducing the carboplatin infusion rate and employing desensitization protocols with anti-allergy medications. Incidence and intensity of anaphylaxis/hypersensitivity events: Table: 138P Discontinuations due to anaphylaxis/hypersensitivity were rare for PH IV (generally <1% except two TRYPHAENA arms: 1% and 3%); no discontinuations of PH FDC SC have been recorded so far. The ESMO Expert Consensus Statement series of publications contain recommendations on well-defined, controversial or clinically relevant topics and are produced by 20-40 key experts in the field. By delivering the target, Symptoms and signs of hypersensitivity reactions amendable to desensitization. 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Leuk Lymphoma. Necessary cookies enable core functionality. All funding for this site is provided directly by ESMO. These scores have been defined by the guideline authors and validated by the ESMO Translational Research and Precision Medicine Working Group.17 g Selpercatinib is EMA approved for treating adults with advanced or metastatic RET fusion-positive TC who had already received lenvatinib or sorafenib. Oncol. Int. doi: 10.1111/j.1525-1438.2005.00136.x, Koshiba, H., Hosokawa, K., Kubo, A., Miyagi, Y., Oda, T., Miyagi, Y., et al. Among cases developing carboplatin-related hypersensitivity reactions, the median number of cycles is 912, and the median doses 6,0008,000 mg. Reported risk factors for carboplatin-related hypersensitivity reactions include carboplatin cycle/dose, platinum-free interval, and history of drug allergies (Libra et al., 2003; Confino-Cohen et al., 2005; Schwartz et al., 2007; Koshiba et al., 2009). Front. All funding for this site is provided directly by ESMO. Among these 75 women, 16 (21.3%) experienced severe hypersensitivity reactions (grades 3 and 4). Women are more affected by drug allergy and up to 27% of women with ovarian and breast cancer develop carboplatin allergy after multiple cycles of treatment. Enhancing the feasibility of outpatient daratumumab administration via a split-dosing strategy with initial doses. Hypersensitivity & Infusion Reaction Management Author: Updated 2.21.19 Subject: SCC Pharmacy The results of the trial could answer whether carboplatin hypersensitivity patients have similar chemo-responses in non-platinum regimens without compromising the efficacy of the antineoplastic regimens of these patients. and transmitted securely. Bethesda, MD 20894, Web Policies Haanen JBAG, Carbonnel F, Robert C, Kerr KM, Peters S, Larkin J, Jordan K; ESMO Guidelines Committee. Vaccines (Basel). 2014;24(2):72-9; quiz 2 p following 79. Platinum-based combination chemotherapy is the recommended treatment for platinum-sensitive recurrent ovarian cancer (Parmar et al., 2003; Pfisterer et al., 2006; Pujade-Lauraine et al., 2010). The incidence of carboplatin-related hypersensitivity correlated with cycle number and dose, with the first episode occurring at a median of 12 cycles and 6,816 mg. Adnan A, Acharya S, Alenazy LA, de Las Vecillas L, Giavina Bianchi P, Picard M, Calbache-Gil L, Romero-Pinedo S, Abad A-Molina AC, Kerr W, Pedicone C, Nagai J, Hollers E, Dwyer D, Castells M. J Immunol. Authors: S. Rosell, I. Blasco, L. Garca Fabregat, A. Cervantes and K. Jordan These recommendations aim to develop guidance to mitigate the negative effects of the COVID-19 pandemic on the diagnosis and treatment of cancer patients. MBC: CLEOPATRA (NCT00567190; PMID 22149875, 23602601, 25693012; 32171426), MetaPHER (NCT02402712; 33748921); EBC: APHINITY (NCT01358877; 28581356, 33539215), NeoSphere (NCT00545688; 22153890, 27179402), TRYPHAENA (NCT00976989; 23704196, 29223479), BERENICE (NCT02132949; 29253081, SABCS 2017 P5-20-04), FeDeriCa (NCT03493854; 33357420), PHranceSCa (NCT03674112; ESMO 2020 165MO). All funding for this site is provided directly by ESMO. The essential content of the guidelinesin condensed slide format in PDF or PowerPoint. Markman et al. Webcasts and presentations from ESMO 2017 can be accessed by ESMO members and event attendees. Parmar et al. Drafting of manuscript: Y-HT and W-FC. A history of drug or food allergy, the presence of malignant ascites, and the cumulative carboplatin dose are three independent predictive factors of carboplatin hypersensitivity in this survey. There is a need to further characterise risk of anaphylaxis/hypersensitivity with PH IV/PH FDC SC to support safe administration outside of clinics. LUGANO-MADRID, 09 September, 2017 -The preliminary results of a study to be presented at the ESMO 2017 Congress in Madrid (1) show that socio-psychological factors have become more significant for . Table 5 reports the incidences of carboplatin hypersensitivity and patient characteristics reported in various investigations, including the present study. Rapid drug desensitization for hypersensitivity reactions to chemotherapy and monoclonal antibodies in the 21st century. doi: 10.1016/S0140-6736(03)13718-X, Pfisterer, J., Plante, M., Vergote, I., du Bois, A., Hirte, H., Lacave, A. J., et al. One-fifth of these patients never attempt carboplatin reinfusion, even after only mild hypersensitivity reactions (Gadducci et al., 2008). Curr Allergy Asthma Rep. 2023 Jan;23(1):1-11. doi: 10.1007/s11882-022-01052-z. Accessibility Cardiopulmonary resuscitation and endotracheal intubation were performed, but the patient finally expired due to respiratory failure. government site. European Hematology Association (EHA) and European . Timetrend analyses showed that most events were reported during the first 68 cycles with concurrent chemotherapy, with a decrease in later cycles (except MetaPHER). Gynecol. Cancer 15, 1318. EHA Endorsement of ESMO Clinical Practice Guidelines for Diagnosis, Treatment, and Follow-up for Myelodysplastic Syndromes. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Same-Day Desensitization in Patients Who Experience Their First Reaction to a Platin Agent at the Oncology Day Unit: A Pilot Study to Safely Include This Technique Within the Multidisciplinary Pathways for the Diagnosis & Management of Hypersensitivity to Platin Agents. Before 2017 Jun 20;18(6):1316. doi: 10.3390/ijms18061316. ESMO Call to Action on COVID-19 Vaccinations and Patients with Cancer: Vaccinate. Cancer 109, 10721078. | DOI: 10.1097/HS9.0000000000000695. ESMO is a Swiss-registered not-for-profit organisation. 18, 615620. Management of uncommon chemotherapy-induced emergencies. de Las Vecillas Snchez L, Alenazy LA, Garcia-Neuer M, Castells MC. Up to 16% of patients with ovarian cancer who undergo treatment with carboplatin-containing regimens experience carboplatin-related hypersensitivity (Markman et al., 1999; Polyzos et al., 2001; Sliesoraitis and Chikhale, 2005). Hypersensitivity reactions to carboplatin administration are common but not always severe: a 10-year experience. Supportive and Palliative Care | ESMO Management of Infusion Reactions to Systemic Anticancer Therapy: ESMO Clinical Practice Guidelines Published in 2017 - Ann Oncol (2017) 28 (suppl 4): iv100-iv118. Epub 2019 Mar 8. (2003). Gerber, C. van den Hurk, P. Fernndez-Peas, D. Santini, F. Jahn, K. Jordan on behalf of the ESMO Guidelines Committee These ESMO Clinical Practice Guidelines provide recommendations on the . The total incidence of carboplatin-related hypersensitivity was 3.21% by the cycle of carboplatin. The characteristics of the 735 patients are presented in Table 2. Lacouture, V. Sibaud, P.A. Educate. (2009). (2005). -. Report of three cases. 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Unauthorized use of these marks is strictly prohibited. doi: 10.1093/annonc/mdx225. Lancet 361, 20992106. doi: 10.1200/JCO.1999.17.4.1141, Moon, D. H., Lee, J. M., Noonan, A. M., Annunziata, C. M., Minasian, L., Houston, N., et al. doi: 10.1006/gyno.1994.1098, Keywords: ovarian cancer, chemotherapy, carboplatin, hypersensitivity, risk factor, Citation: Tai Y-H, Tai Y-J, Hsu H-C, Lee S-P, Chen Y-Y, Chiang Y-C, Chen Y-L, Chen C-A and Cheng W-F (2017) Risk Factors of Hypersensitivity to Carboplatin in Patients with Gynecologic Malignancies. The rate of hypersensitivity to carboplatin did not differ by patient age, menopausal status, disease entity, receipt of optimal debulking, or the amount of ascites. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Cancer 19, 12841287. (2005). Ke. J. Med. Close monitoring is warranted for patients with any one of these three risk factors who are receiving carboplatin. -, Sakaeda T, Kadoyama K, Yabuuchi H, Niijima S, Seki K, Shiraishi Y, et al. Note: Approved by the ESMO Guidelines Committee: July 2017, last update October 2022. . See this image and copyright information in PMC. J Oncol Pract. Epub 2019 Jul 3. Table 1. Nitipir C, Parosanu A, Popa AM, Cotan H, Olaru M, Iaciu C, Orlov Slavu C. Cureus. There is evidence that inhibitory mechanisms blocking IgE/antigen mast cell activation are active during desensitization, enhancing safety. Cisplatinum rechallenge in relapsed ovarian cancer patients with platinum reinduction therapy and carboplatin hypersensitivity. Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). TABLE 3 Table 3. Cancer Sci. The site is secure. Symptoms and signs of 75 patients with hypersensitivity reactions to carboplatin. Study conception and design: Y-HT and W-FC. Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase1 Study of Intravenous Fosnetupitant. Read guidelines by topic Latest Guidelines News Allergy Asthma Proc (2011) 32(1):79.10.2500/aap.2011.32.3409 doi: 10.1016/j.ygyno.2006.10.047, Shah, A. C., Minturn, J. E., Li, Y., Belasco, J. 20, 566573. Acquisition of data: Y-HT, S-PL, Y-CC, Y-LC. Open. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Here, we retrospectively evaluated carboplatin-related hypersensitivity reactions among patients with gynecological cancer (ovarian, fallopian tube, or primary peritoneal cancer) who received carboplatin-containing regimens at a single medical institute in Taiwan. Deleterious BRCA1/2 mutation is an independent risk factor for carboplatin hypersensitivity reactions. We evaluated the prevalence of and risk factors for hypersensitivity reactions related to carboplatin, which is commonly used to treat gynecological malignancies. Front Oncol. 329 (152 CPI-treated v 177 CPI-nave, including 60 tx-nave) pts with RET fusion+ NSCLC were analyzed. (2003) reported that paclitaxel with platinum improves overall survival compared to conventional platinum-based chemotherapy among patients with relapsed platinum-sensitive ovarian cancer. Van Tine BA, Govindarajan R, Attia S, Somaiah N, Barker SS, Shahir A, Barrett E, Lee P, Wacheck V, Ramage SC, Tap WD. We retrieved clinical information, including age, menopausal status, cancer stage, surgical findings, chemotherapeutic treatment history, recurrence status, and survivorship, from the clinical and operative notes and discharge summaries stored in a centralized database.

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