promethazine suppository stability at room temperature

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. The effect of drug concentration on the thermal (dark) degradation of promethazin hydrochloride in aqueous solution. Accessibility Oral or Rectal: 1.1 mg/kg orally or rectally every 4 to 6 hours as needed, 2 years and older: June 14, 2022. Accessibility Established labor: 25 to 75 mg IM or IV, repeated up to 2 times in 4-hour intervals. Household teaspoons may not be an accurate measuring device. Promethazine is in a class of medications called phenothiazines. Store promethazine tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. It works by blocking histamine, a substance released by the body during an Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. 17 H any drug without checking with your doctor. Do not take more or less of it or take it more often than prescribed by your doctor. Do not freeze. endobj Study on absorption of indomethacin from sustained-release suppositories containing hydrogenated soybean lecithin in rabbits. Promethazine is used with other medications to treat anaphylaxis (sudden, severe allergic reactions) and the symptoms of the common cold such as sneezing, cough, and runny nose. PRECAUTIONS- Information for Patients and Drug Interactions, Cosette Pharmaceuticals, Inc. product information by RSS, Additional medications in the Prescription Medications section by. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment Dosage must be individualized. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. <> National Library of Medicine 2013 Mar;75(2):143-8. Patients receiving parenteral formulations should report persistent/worsening pain or burning at the injection site. Epinephrine Because of the potential for promethazine HCl to reverse epinephrines vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Promethazine HCl Suppositories overdose. this version. In some cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required. Tell your doctor if any of these symptoms are severe or do not go away: Some side effects can be serious. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. Convulsions may rarely occur. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects. suppository. Neuroleptic malignant syndrome (potentially fatal) has also been reported (See It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. The release of indomethacin from fatty-base suppositories, which had been stored at a low (4 degrees C) and a high (25-30 degrees C) temperature for about one month, was examined in vitro and in vivo. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man. Avoid prolonged exposure to the sun. If you are allergic to this medicine (promethazine suppositories); any part of this medicine (promethazine suppositories); or any other drugs, foods, or substances. official website and that any information you provide is encrypted WARNINGSBlack Box Warning and Vasomotor rhinitis. Epinephrine Because of the potential for promethazine HCl to reverse epinephrines vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Promethazine HCl Suppositories overdose. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HCl SUPPOSITORIES HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. Remove the wrapper. Manufacturer Contact. Rectal suppositories Never take suppositories by mouth. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. 25 mg, white, bullet-shaped suppository wrapped in silver foil. Talk with the doctor. Read all information given to you. Oral formulations are preferred; however, rectal or parenteral formulations may be given if oral formulations are not tolerated. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Sedative doses may be given the night before surgery. Do not drive a car or operate machinery until you know how this medication affects you. 301-657-3000. This medicine may cause the results of some pregnancy tests to be wrong. Parenteral: Treatment: 12.5 to 25 mg IM, IV, orally, or rectally every 4 hours as needed This drug should not be used to treat nausea and vomiting of unknown etiology. Distributedby: Cosette Pharmaceuticals, Inc. Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic. IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF PROMETHAZINE HCL BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE AVOIDED. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Webtype of IVPB solution will be stored at room temperature (21C), 4C, and 37C in the dark. PROMETHAZINE HCL SUPPOSITORIES SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION. Promethazine HCl Suppositories may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Promethazine HCl is a racemic compound; the empirical formula is C 17 H 20 N 2 SHCl and its molecular weight is 320.88. Take promethazine exactly as directed. In 1987, Sterchele5 described the WebA stability-indicating GLC method for the analysis of promethazine hydrochloride in polyethylene glycol delivery systems is reported. HHS Vulnerability Disclosure, Help Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. There may be drug take-back programs in your area. WebStability at Room Temperature** FOR SPECIFIC INFORMATION, CONTACT MANUFACTURER Unopened vial should not be left at room temperature for a total time exceeding 12 hours prior to use. Remove the foil wrapper and insert the suppository high into the posterior vaginal fornix. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. http://goo.gl/c4Rm4p 1 receptor blocking agent. To report SUSPECTED ADVERSE REACTIONS, contact Cosette Pharmaceuticals, Inc. at 1-800-922-1038 or FDA at 1-800-FDA-1088 or Promethazine HCl Suppositories should be used cautiously in persons with cardiovascular disease or with impairment of liver function. Unable to load your collection due to an error, Unable to load your delegates due to an error. Shakiness, trouble moving around, or stiffness. When promethazine is used to treat motion sickness, it is taken 30 to 60 These results suggest that in conscious rats many factors such as a locomotor hyperactivity and enhancement of gastrointestinal motility caused by the rectal administration mask the real character of suppositories. Comments: 2 years and older: Signs and symptoms of overdosage with promethazine HCl range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, and unconsciousness, and sudden death. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Do not take a double dose to make up for a missed one. Put suppository into the rectum with gentle pressure, pointed end first. Caution should be exercised when administering parenteral formulations in pediatric patients 2 years of age and older; it is recommended that the lowest effective dose of oral formulations be used in and concomitant administration of other drugs with respiratory depressant effects be avoided in this patient population. Phenergan, Promethegan, Antinaus 50, Phenadoz. Carcinogenicity Under the conditions of the National Toxicology Program (NTP) studies, there was no evidence of Adjunctive therapy to epinephrine and other standard measures for anaphylactic reactions, after acute manifestations have been controlled, Parenteral: 6.25 to 12.5 mg IM or IV every 4 hours a day, Oral and Rectal: 12.5 to 25 mg orally or rectally 2 times a day. Tell all of your health care providers that you take this medicine (promethazine suppositories). 8600 Rockville Pike government site. Privacy Policy | Copyright 2023. Methods: During a 12-month period ending in June 2021, the prescribing information and published Allergic conjunctivitis due to inhalant allergens and foods, Amelioration of allergic reactions to blood or plasma, In anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, Mild, uncomplicated allergic skin manifestations of urticaria and angioedema, Other uncomplicated allergic condition of the immediate type when oral therapy is impossible or contraindicated, Early stages of labor: 50 mg IM or IV once, Nighttime sedation: 25 to 50 mg IM or IV once. Promethazine is used to relieve the symptoms of allergic reactions such as allergic rhinitis (runny nose and watery eyes caused by allergy to pollen, mold or dust), allergic conjunctivitis (red, watery eyes caused by allergies), allergic skin reactions, and allergic reactions to blood or plasma products. Insert the suppository Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking promethazine. Vials stored at room temperature should not be returned to the refrigerator. This site complies with the HONcode standard for trustworthy health information: verify here. View Labeling Archives, Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. https://medlibrary.org/lib/rx/meds/promethegan-5/. This site is provided for educational and informational purposes only, in accordance with our Terms of Use, and is not intended as a substitute for the advice of a medical doctor, nurse, nurse practitioner or other qualified health professional. Promethazine is also used to prevent and treat motion sickness. Tell your with your doctor, nurse, pharmacist, or other health care provider. https://www.poisonhelp.org/help The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment Medically reviewed by Drugs.com. Do not take more often than told by the doctor. Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. The https:// ensures that you are connecting to the Protect the medication from light. HHS Vulnerability Disclosure, Help Federal government websites often end in .gov or .mil. Files, Presentations For nausea and vomiting in children, the usual dose is 0.5 mg per pound of body weight, and the dose should be adjusted to the age and weight of the patient and the severity of the condition being treated. Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults. Keep all drugs out of the reach of children and pets. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Clinical Trials, WebPromethazine Hydrochloride Sensitization Not applicable. Only in cases of extreme overdosage or individual sensitivity do vital signs, including respiration, pulse, blood pressure, temperature, and EKG, need to be monitored. 03/2020 VC7409, Boxed Warnings, xlI=ZMju! @ jzkZ$q{)w/_?FUV2Eg5nnf?eo w#T[)rUmp2ly!`w13?G]_LhFPpCsQH7ir_&C'57:/ The impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should either be eliminated or given in reduced dosage in the presence of promethazine HCl (see Talk to your doctor about the risks of giving promethazine to your child. Alcohol can make the side effects of promethazine worse. PROMETHAZINE HCL SUPPOSITORIES ARE CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE (see WARNINGS-Black Box Warning and Use in Pediatric Patients). Oxygen may also be administered. talk to your doctor about the risks and benefits of taking promethazine if you are 65 years of age or older. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Monoamine Oxidase Inhibitors (MAOI) Sedation Promethazine HCl Suppositories may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions. It may be given to you for other reasons. WARNINGSCNS Depression and The American Society of Health-System Pharmacists It is used to help motion sickness . Promethazine HCl Rectal Suppositories, USP are available in boxes of 12 and 1000 as follows: 12.5 mg, white, bullet-shaped suppository wrapped in silver foil. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Diazepam may be used to control convulsions. Promethazine is well absorbed from the gastrointestinal tract. In the event that vasopressors are considered for the management of severe hypotension that does not respond to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine should be considered. sharing sensitive information, make sure youre on a federal This method is capable of distinguishing Promethazine HCl 12.5mg. Drowsiness is the most prominent CNS effect of this drug. IV formulations should be diluted to a concentration of 25 mg/mL or less. If you have high blood sugar (diabetes), you will need to watch your blood sugar closely. Drug classes: Antihistamines, Phenothiazine antiemetics. Promethazine is an H 25 mg, white, bullet-shaped suppository wrapped in silver foil. Phenergan (Promethazine HCl) Suppositories are for rectal administration only. Get Label RSS Feed, If you are a consumer or patient please visit To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Respiratory Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). POSTMARKETING CASES OF RESPIRATORY DEPRESSION, INCLUDING FATALITIES, HAVE BEEN REPORTED WITH USE OF PROMETHAZINE HCL SUPPOSITORIES IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE. Maximum dose: 25 Promethazine HCl Rectal Suppositories are not recommended for children under 2 years of age. Once treatment begins, the dose should be reduced to the smallest effective amount needed to control symptoms. J Pharm Pharmacol. Promethazine HCl 50mg. Bookshelf If you are giving promethazine to a child, watch the child to be sure he or she does not get hurt while riding a bike or participating in other activities that could be dangerous. When promethazine is used to treat or prevent nausea and vomiting it is usually taken every 4 to 6 hours as needed. Do not Please enable it to take advantage of the complete set of features! plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. H-Phenothiazine, 10-ethanamine, The https:// ensures that you are connecting to the Allergy The average dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. If you become pregnant while taking promethazine, call your doctor. In conscious rats, the plasma indomethacin levels attained after the intrarectal administration of suppositories stored at a high temperature were slightly lower than those after the animals were given suppositories stored at a low temperature, but the difference was significant only 30 min after administration. All oral versions (tablets, syrup) of promethazine should be stored in the original, labeled container at room temperature. Disclaimer. http://www.fda.gov/Safety/MedWatch This site needs JavaScript to work properly. Store promethazine suppositories in the refrigerator. Within the Prescription Medications section: Use Trial Bulletin to search for clinical trials involving this product: All MedLibrary.org resources are included in as near-original form as possible, meaning that the information from the original provider has been rendered here with only typographical or stylistic modifications and not with any substantive alterations of content, meaning or intent. On longer trips, promethazine is usually taken in the morning and before the evening meal on each day of travel. A&k]h/+ulm.d!*/XHvPr]SjTHc%t ?($uL Db~4;22bt`gE[6Pi*8G:#k:V`BQS=X9R2N$ARz ]x~#RVY2ZdVX lr+baz|To+-$`>*>c 7o&. RxNorm, Lie down on your left side and raise your right knee to your chest. PRECAUTIONSDrug Interactions). Promethazine suppositories are for rectal use only. Federal government websites often end in .gov or .mil. Use of Promethazine HCl Suppositories in patients with compromised respiratory function (e.g., COPD, sleep apnea) should be avoided. Glucose Tolerance Test Promethazine HCl Suppositories may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. FOIA Purpose: The aim of this review was to build upon previous literature describing the maximum duration for which refrigerated medications can tolerate room temperature excursions while maintaining stability and potency. Hematologic Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis. Teratogenic Effects - Pregnancy Category C Also tell your doctor and pharmacist if you have ever had an unusual or unexpected reaction when you took promethazine, another phenothiazine, or any other medication. The injection solution should be inspected for particulate matter and discoloration before administration. Do not start, stop, or change the dose of prednisone, trazodone, hydroxyzine, ondansetron, montelukast, fluticasone nasal, lorazepam, loratadine, cetirizine, diazepam. This report on medications is for your information only, and is not considered individual patient advice. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Promethazine HCl Suppositories should be used cautiously in persons with cardiovascular disease or with impairment of liver function. Post-marketing cases of respiratory depression, including fatalities, have been reported with use of this drug in pediatric patients less than 2 years of age. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Box of 12 NDC 0713-0536-12 Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Last updated on Apr 10, 2023. solution. We comply with the HONcode standard for trustworthy health information. Central Nervous System Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Promethazine HCl Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. Promethazine may cause breathing to slow or stop, and may cause death in children. 3 0 obj Available for Android and iOS devices. WebPROMETHAZINE (proe METH a zeen) prevents and treats the symptoms of an allergic reaction. Take the missed dose as soon as you remember it. The average adult dose is 25 mg taken twice daily. PMC Clinical studies of promethazine formulations did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. to you and the baby. If the suppository feels soft, hold it under cold, running water for 1 minute. Cardiovascular Increased or decreased blood pressure, tachycardia, bradycardia, faintness. Unable to load your collection due to an error, Unable to load your delegates due to an error. Indomethacin sustained-release suppositories containing sugar ester in polyethylene glycol base. official website and that any information you provide is encrypted The in vitro and in vivo results show that the release of indomethacin from fatty-base suppositories stored at a high temperature is less than the release from those stored at a low temperature. Dispense in well-closed container. It is thought that this configuration is responsible for its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. The following laboratory tests may be affected in patients who are receiving therapy with promethazine HCl: Last updated on Jan 28, 2022. Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. Promethazine HCl 50mg. WebWhen promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. Low white blood cell counts have happened with this medicine (promethazine suppositories). Bethesda MD 20814 Follow all instructions closely. Preoperative medication: 1.1 mg/kg IM, IV, orally, or rectally once. The first-order rate constant increased with increasing pH. Generic alternatives may be available. Avoid analeptics, which may cause convulsions. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=5f079815-f48b-8b21-2130-7f791d967c9a, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. To insert a promethazine suppository, follow these steps: Unless your doctor tells you otherwise, continue your normal diet. The average effective dose of promethazine HCl for the active therapy of nausea and vomiting in children or adults is 25 mg. 12.5- to 25-mg doses may be repeated, as necessary, at 4- to 6-hour intervals. Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. J Pharm Pharmacol. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Respiratory rate, especially in pediatric patients. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. 1989 Nov;37(11):3145-7. doi: 10.1248/cpb.37.3145. Promethazine was nonmutagenic in the South Plainfield, NJ 07080 Would you like email updates of new search results? if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking promethazine. Perennial and seasonal allergic rhinitis. The initial dose should be given 30 to 60 minutes before anticipated travel, and may be repeated in 8 to 12 hours as needed. www.fda.gov/medwatch. Promethazine HCl, a phenothiazine derivative, is designated chemically as 10 Use. If your child is throwing up for an unknown reason. Tell your doctor or pharmacist about all the medications your child is taking, especially barbiturates such as phenobarbital (Luminal), medications for anxiety, narcotic medications for pain, sedatives, sleeping pills, and tranquilizers. The .gov means its official. There are many drugs that Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in children who are 2 years of age older and 1 inch (2.5 centimeters) in adults. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Kinetic studies were performed to determine the photolytic and thermal degradation rates of promethazine hydrochloride as a function of pH. Paradoxical Reactions If you have any questions about this medicine (promethazine suppositories), please talk Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). Ask the doctor or pharmacist if you are not sure. Active and prophylactic treatment of motion sickness. 1990 Apr;38(4):1027-31. doi: 10.1248/cpb.38.1027. Talk with the doctor. Medically reviewed by Drugs.com. Unauthorized use of these marks is strictly prohibited. CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING PROMETHAZINE HCL TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER. Antiemetics should not be used in vomiting of unknown etiology in children and adolescents (see Preoperative, postoperative, or obstetric sedation. drugs that can do this. can do this. Prophylaxis: Parenteral: Indomethacin sustained-release suppositories containing sugar ester. Hallucinations (seeing or hearing things that are not there). Promethazine HCl is a racemic compound; the empirical formula is C 17H 20N 2SHCl and its molecular weight is 320.88. For preoperative medication children require doses of 0.5 mg per pound of body weight in combination with an appropriately reduced dose of narcotic or barbiturate and the appropriate dose of an atropine-like drug. A linear relationship between peak height ratio (promethazine-promazine) and promethazine concentration is found up to a concentration of 600 micrograms/ml. Antiemetic therapy in postoperative patients. This drug should be administered at a rate no greater than 25 mg/min. Promethazine should not routinely be used to treat vomiting in children; it should only be used in specific cases when a doctor decides that it is needed. Promethazine can cause side effects. Parenteral formulations of this drug may cause severe chemical irritation and tissue damage regardless of the route. This method is capable of distinguishing the intact drug from its thermal and photodegradation products. Usual adult dosage is 50 mg promethazine HCl with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid. is this? See the FDA's Safe Disposal of Medicines website ( Copyright, 2023. Patients should be advised to report any involuntary muscle movements. This site needs JavaScript to work properly. Promethazine is an H Avoid prolonged exposure to the sun. AHFS % 8600 Rockville Pike Call your doctor or get medical ) for more information if you do not have access to a take-back program. Parenteral: 25 mg IM or IV once, and may be repeated within 2 hours if necessary This method is capable of distinguishing the intact drug from its thermal and photodegradation products.

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